diff --git a/compiler/driver/compiler_driver.cc b/compiler/driver/compiler_driver.cc
index 52ffa55..7e91453 100644
--- a/compiler/driver/compiler_driver.cc
+++ b/compiler/driver/compiler_driver.cc
@@ -1054,11 +1054,16 @@
 }
 
 bool CompilerDriver::ShouldCompileBasedOnProfile(const MethodReference& method_ref) const {
+  // Profile compilation info may be null if no profile is passed.
   if (!CompilerFilter::DependsOnProfile(compiler_options_->GetCompilerFilter())) {
     // Use the compiler filter instead of the presence of profile_compilation_info_ since
     // we may want to have full speed compilation along with profile based layout optimizations.
     return true;
   }
+  // If we are using a profile filter but do not have a profile compilation info, compile nothing.
+  if (profile_compilation_info_ == nullptr) {
+    return false;
+  }
   bool result = profile_compilation_info_->ContainsMethod(method_ref);
 
   if (kDebugProfileGuidedCompilation) {
diff --git a/dex2oat/dex2oat_test.cc b/dex2oat/dex2oat_test.cc
index 6881f75..2c0b125 100644
--- a/dex2oat/dex2oat_test.cc
+++ b/dex2oat/dex2oat_test.cc
@@ -554,6 +554,12 @@
   RunTest(CompilerFilter::kSpeed, true, { "--very-large-app-threshold=100" });
 }
 
+// Regressin test for b/35665292.
+TEST_F(Dex2oatVeryLargeTest, SpeedProfileNoProfile) {
+  // Test that dex2oat doesn't crash with speed-profile but no input profile.
+  RunTest(CompilerFilter::kSpeedProfile, false);
+}
+
 class Dex2oatLayoutTest : public Dex2oatTest {
  protected:
   void CheckFilter(CompilerFilter::Filter input ATTRIBUTE_UNUSED,