diff --git a/apex/apex_test.go b/apex/apex_test.go
index e618589..5f4cfac 100644
--- a/apex/apex_test.go
+++ b/apex/apex_test.go
@@ -1209,16 +1209,22 @@
 	mylibCFlags := ctx.ModuleForTests("mylib", "android_arm64_armv8-a_core_static").Rule("cc").Args["cFlags"]
 	ensureNotContains(t, mylibCFlags, "-D__ANDROID_APEX__=myapex")
 	ensureNotContains(t, mylibCFlags, "-D__ANDROID_APEX__=otherapex")
+	ensureNotContains(t, mylibCFlags, "-D__ANDROID_APEX_MYAPEX__")
+	ensureNotContains(t, mylibCFlags, "-D__ANDROID_APEX_OTHERAPEX__")
 
 	// APEX variant has __ANDROID_APEX__=<apexname> defined
 	mylibCFlags = ctx.ModuleForTests("mylib", "android_arm64_armv8-a_core_static_myapex").Rule("cc").Args["cFlags"]
 	ensureContains(t, mylibCFlags, "-D__ANDROID_APEX__=myapex")
 	ensureNotContains(t, mylibCFlags, "-D__ANDROID_APEX__=otherapex")
+	ensureContains(t, mylibCFlags, "-D__ANDROID_APEX_MYAPEX__")
+	ensureNotContains(t, mylibCFlags, "-D__ANDROID_APEX_OTHERAPEX__")
 
 	// APEX variant has __ANDROID_APEX__=<apexname> defined
 	mylibCFlags = ctx.ModuleForTests("mylib", "android_arm64_armv8-a_core_static_otherapex").Rule("cc").Args["cFlags"]
 	ensureNotContains(t, mylibCFlags, "-D__ANDROID_APEX__=myapex")
 	ensureContains(t, mylibCFlags, "-D__ANDROID_APEX__=otherapex")
+	ensureNotContains(t, mylibCFlags, "-D__ANDROID_APEX_MYAPEX__")
+	ensureContains(t, mylibCFlags, "-D__ANDROID_APEX_OTHERAPEX__")
 }
 
 func TestHeaderLibsDependency(t *testing.T) {
diff --git a/cc/compiler.go b/cc/compiler.go
index 85ff400..f45ee58 100644
--- a/cc/compiler.go
+++ b/cc/compiler.go
@@ -321,7 +321,9 @@
 	}
 
 	if ctx.apexName() != "" {
+		// TODO(b/142582178): remove the value for __ANDROID_APEX__
 		flags.GlobalFlags = append(flags.GlobalFlags, "-D__ANDROID_APEX__="+ctx.apexName())
+		flags.GlobalFlags = append(flags.GlobalFlags, "-D__ANDROID_APEX_"+makeDefineString(ctx.apexName())+"__")
 	}
 
 	instructionSet := String(compiler.Properties.Instruction_set)
@@ -529,6 +531,12 @@
 	return false
 }
 
+// makeDefineString transforms a name of an APEX module into a value to be used as value for C define
+// For example, com.android.foo => COM_ANDROID_FOO
+func makeDefineString(name string) string {
+	return strings.ReplaceAll(strings.ToUpper(name), ".", "_")
+}
+
 var gnuToCReplacer = strings.NewReplacer("gnu", "c")
 
 func ndkPathDeps(ctx ModuleContext) android.Paths {